Herbs that Drain Fire

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What are the signs and symptoms associated with Yang Ming channel disease?
Yang Ming channel disease (aka Qi level heat) are characterized by the "Four Bigs" or "Four Greats," which are treated using Herbs that Drain Fire.

Source: Wiseman and Ellis (1996). Fundamentals of Chinese Medicine. Brookline, MA: Paradigm Publications. p. 229 [Q360]